Abstract
Pregnancy loss occurs more frequently both in twin gestations and when mothers smoke cigarettes. Data are presented which indicate an interaction between maternal smoking and placentation in twin pregnancies. Two sets of twin data were analyzed. Seventy-six twin pregnancies were collected prospectively at 7 Denver hospitals. Medical and smoking histories were obtained by interview and smoking was corroborated by cord blood thiocyanate levels for the last 35 deliveries. Twins were classified as monozygotic (MZ) or dizygotic (DZ) based on placentation, sex and bloodtyping of 20 antigens. Placentas were classified as dichorionic (DC) or monochorionic (MC) by gross and microscopic examination. Data on 457 twin pregnancies were also obtained through the National Collaborative Perinatal Project (NCPP). Independence of the variables: zygosity, placentation, and smoking were tested using contingency analysis. Observed (OBS) and expected (EXP) values were:Fewer than the expected number of MZ-MC twins were delivered in both groups when mothers smoked. Additional variables (sex, race, amount of smoking, and a perinatal outcome) were controlled for in the interaction and a dose-dependent trend was seen.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
