4-6THE ASSOCIATION OF DNA METHYLATION OF A-ADDUCIN IN ESSENTIAL HYPERTENSION: A QUALITATIVE SYSTEMATIC REVIEW

Abstract

Introduction: Essential hypertension (EH) is one of the most common health problems with significant mortality and morbidity in the world. EH is a complex multifactorial disease resulting from both genetic and environmental factors. α-Adducin (ADD1) is one of several genetic markers that have been identified. DNA methylation is defined as the addition of a methyl group to the DNA molecule, which associated with a change in the activity of DNA segment without the affection of its sequence. Method: We comprehensively searched case-control studies about essential hypertension and α-adducin in electronic databases including PubMed, EMBASE, and JSTOR. Results: Those three studies (a total 1203 cases and 1148 controls) results were relatively similar, the ADD1 CpG2-5 methylation level was significantly associated with EH, lower CpG1 methylation level was associated with increased risk of EH in females while lower CpG2-5 methylation was associated with an increased risk of EH in males significantly. Discussion: EH is an age-related chronic condition affecting males more than females. We found that DNA methylation of ADD1 gene was significantly higher in females than in males. Adducin was implicated in the pathogenesis of EH by modulating Na+-K+-ATPase activity. CpG1 methylation can predict EH among females, and CpG2-5 methylation does among males. Conclusion: There was an association of DNA methylation of α-Adducin with essential hypertension.