46P Enhanced 5-aminolaevulinic acid (ALA)-based photodynamic therapy (PDT) efficacy by hormones in uterine sarcoma cells via upregulation of proporphyrinogen oxidase

Abstract

Photodynamic therapy (PDT) is an FDA approved cancer treatment modality for various cancers. In principle, PDT induces a photochemical reaction with exogenous photosensitizer (PS) in cancer cells upon light irradiation with oxygen, which generates reactive oxygen species leading to cancer cell death. Studies showed that hormones enhanced accumulation of photosensitive protoporphyrin IX (PpIX) generated by ALA PS in human endometrial cells, implying the increased PpIX potentially boost up ALA-based PDT effect in hormonal dependent cancers.