Abstract
Introduction: Oral squamous cell carcinomas (OSCC) are aggressive cancer types because of their invasiveness,ability to metastasize locoregionally, and relative resistance to nonsurgical therapies. Transcription factors are molecular targets with known importance in mechanisms of tumorigenesis of OSCC. For example, the transcription factors NF-kB and AP-1 are upregulated in OSCC in a constitutive fashion. This activation correlates functionally with the production of pro-inflammatory cytokines that enhance angiogenesis, mitogenesis, and invasion. ATF2 has been implicated in the regulation of genes that play roles in apoptosis, survival and tumor progression in other cell systems. It also partners with many transcription factors such as c-Jun to initiate transcriptional activity. Recently, ATF2 has also been identified as an executor of apoptosis in poorly differentiated tumor cells. Here we demonstrate that ATF2 can be downregulated in OSCC using siRNA. We also show that decreasing ATF2 in the human oral tongue carcinoma cell line UMSCC 9 affects resistance of cells to staurosporin-mediated growth inhibition.
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