Abstract
Normally, when adenoviral vectors (AdVs) are administered by intravascular injection, the majority of the vector is rapidly cleared from the circulation by the reticuloendothelial system (RES), primarily by Kupffer cells (KCs), specialized macrophages that reside in liver sinusoids. This results in a rapid innate immune response and subsequent liver pathology. In cirrhotic animals, however, we have previously shown that the biodistribution of intravenously administered AdVs is altered due to the presence of pulmonary intravascular macrophages (PIMs), which cause a shift in RES vector uptake from the liver to the lungs. We report here that this is correlated with fatal pulmonary hemorrhagic edema.
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