Abstract
Cutaneous T-cell lymphomas (CTCL) are rare non-Hodgkin lymphomas of skin-tropic T cells. Advanced-stage CTCL are frequently refractory to treatment and early relapses are common. There is a clear unmet need for new treatments with long-term efficacy in CTCL. CCR8 is a chemokine receptor expressed by skin resident memory T cells which are suspected to be the tumor cells of origin in mycosis fungoides. CCR8 is also strongly expressed by tumor-infiltrating Treg involved in immune escape. We combined blood flow cytometry in 13 patients with CTCL and healthy controls, in vitro stimulation of CTCL patients cells, Nanostring gene expression analysis, and single cell RNA sequencing analysis on human CTCL skin to study CCR8 expression and function in CTCL.
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