Abstract
There is a critical unmet need for next generation targeted therapies with improved efficacy and tolerability for patients with metastatic urothelial carcinoma. Resistance to FGFR targeted therapies can be mediated by an acquired gatekeeper mutation, yet no approved therapies are available in this setting. TYRA-300 is an FGFR3-selective inhibitor agnostic to the gatekeeper mutation, with less hyperphosphatemia mediated by FGFR1 inhibition than pan-FGFR inhibitors in preclinical models.
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