Abstract
The Allomap, a peripheral blood transcriptomic signature to predict cardiac allograft rejection, has been recently introduced into clinical practice. This gene signature, developed using bioinformatic platforms, has not been validated with intragraft events. We sought to analyze transcriptomic expression of IL1R2, PDCD-1 and FLT3, the principle genes in the Allomap system associated with ongoing and future cellular rejection, using splenocytes and cardiac allograft tissues from a heterotopic cardiac transplant rat model.
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