Abstract
Introduction: Chronic liver disease/cirrhosis (CLD) in individuals produces a variety of symptoms which in turn lead to a negative impact on health-related quality of life (HRQOL). However, no such work has been carried out in Pakistan. The general aim of this study was to evaluate the magnitude of poor HRQOL and to assess factors related with HRQOL in patients with CLD. Method: A cross-sectional study was conducted at the Gastroenterology Clinics of Aga Khan University Hospital. All adult patients diagnosed to have cirrhosis were invited to participate. In this study, Chronic Liver Disease Questionnaire (CLDQ) was used to assess HRQOL of these patients. Patients were categorized into 2 groups based on CLDQ score; <5 as poor and ≥5 as good score for determination of the frequency of poor HRQOL. CLDQ score was used as an outcome measure to determine the factors related with HRQOL. Result: Two-hundred and seventy-three participants were recruited; 155 (57%) were males. Mean age of participants was 49 years (SD ± 11 years). In this study, the most common cause for cirrhosis was viral infection 247 (91.5%). Mean Child Turcot Pugh (CTP) score was 8 ± 1.85 and the mean model for end stage liver disease (MELD) score was 12.6 ± 6.8. Two-hundred and nine patients (76.6%) had CTP B or C class. Poor HRQOL was seen in 187 (69%) of the participants. Mean CLDQ score was 4.36 (SD ± 1.1). Among all of the domains, fatigue domain had significantly lower CLDQ score. On multivariable analysis, hemoglobin (β = 0.09 [SE = 0.04]), albumin (β = 0.32 [SE = 0.09]), diastolic blood pressure (DBP) (β = 0.01 [0.005]), and prior history of decompensation (β = 0.98 [SE = 0.39] were the significant factors associated with HRQOL in patients with liver cirrhosis. Conclusion: Frequency of poor HRQOL determined by CLDQ score is high in patients with liver cirrhosis. Hemoglobin, serum albumen, diastolic blood pressure and prior history of decompensation are associated with HRQOL. 45
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
