Abstract
Highly porous 45S5 bioactive glass-based scaffolds prepared by foam replication method were coated with cellulose nanowhiskers by dip coating method. The obtained cellulose nanowhisker-coated scaffolds retained the high porosity and interconnected pore structure. The cellulose coating improved the mechanical properties of the scaffolds and did not hinder their bioactivity in simulated body fluid. In vitro biocompatibility assessment was carried out by qualitative evaluation of the morphology of osteoblast-like cells (MG-63) seeded onto the scaffolds. The cells were shown to attach and spread on both uncoated scaffolds and cellulose nanowhisker-coated scaffolds, thus cellulose nanowhisker coating seems to have no negative influence on the behavior of MG-63 cells. The obtained bioactive and biocompatible composite scaffolds represent promising candidates for bone tissue engineering applications.
Highlights
With an increasing aging population, there is a high demand for bone gra s for repairing bone defects caused by trauma, tumor or bone related diseases.[1]
Porous 45S5 bioactive glass (BG)-based scaffolds fabricated by foam replication method are strong enough for manual handling, the obtained mechanical properties are still not enough for bone tissue engineering application in load-bearing conditions.[10]
The present study extends the understating of the cytocompatibility of cellulose nanowhiskers containing composite materials to osteoblast-like cells, and con rms the cytocompatibility of cellulose nanowhiskers coated 45S5 BG-based scaffolds to MG-63 cells
Summary
With an increasing aging population, there is a high demand for bone gra s for repairing bone defects caused by trauma, tumor or bone related diseases.[1]. Autologous bone gra ing is bound by several constraints, such as limited amount of tissue that can be harvested, requirement of a secondary surgery and risk of infection.[1,2] a large number of bone substitutes made of engineered materials are under investigation in the context of tissue engineering. Such substitutes, called scaffolds, exhibit 3D high porosity and suitable surface properties and degradation behavior.. Different polymers are being used to coat 45S5 BG-based scaffolds.[11,12,13,14,15] In
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