459 Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle

Abstract

<h3>Introduction/Background</h3> Implantation failure is a major problem in reproductive medicine, and despite the various methods described for treatment, there is little consensus on the most effective method. Therefore, this study was conducted to investigate the effect of intrauterine injection of platelet-rich plasma (PRP) on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization (IVF) cycle. <h3>Methodology</h3> In this clinical trial study, women attending the infertility clinic of Ali ibn Abitaleb Hospital in Zahedan (Iran) in 2019, who had a history of implantation failure and were candidates for frozen embryo transfer (FET), were examined. After receiving informed consent, the patients were divided into two groups of PRP recipients and the control group. IVF was performed routinely, and in the PRP receiving group, intrauterine injection was performed 48 hours before embryo transfer (ET). Then, demographic factors such as age, body mass index (BMI) and endometrial thickness were investigated in the two groups. The number of gestational sacs, the rate of implantation, the frequency of chemical and clinical pregnancies, as well as the frequency of abortion were compared in two groups. <h3>Results</h3> In this study, 90 patients with a history of implantation failure participated the study and finally the information of 85 patients was studied. The mean age of the patients as well as the BMI did not differ between the two groups. The frequency of chemical pregnancy was 40% in the experimental group, 27% in the control group, and regarding clinical pregnancy 33% in the experimental group, and 24% in the control group, but there was no significant difference between the two groups. The rate of implantation, the mean thickness of the endometrium and the frequency of abortion did not differ significantly between the two groups. <h3>Conclusion</h3> In general, the results of this study showed that in patients with endometrial thickness greater than 8 mm with a history of recurrent implantation failure, intrauterine injection of PRP had no effect on fertility outcome. <h3>Disclosures</h3> None.