Abstract
The lentiviral genome non-specifically integrates into the human genome and this can lead to insertional mutagenesis and potentially cell transformation. We are using two strategies to eliminate the risk of insertional mutagenesis thereby improving the safety and efficacy of lentiviral gene therapy vectors. The first is to develop non-integrating lentiviral vectors and the second is to target integration to a non-pathogenic site in the human genome.
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