Abstract
Plasminogen activating inhibitor-1 (PAI-1) is classically known as an angiogenesis promoting factor that is associated with poor clinical outcomes in various cancers, including skin cancer such as cutaneous melanomas. Cutaneous angiosarcoma (CAS) is a vascular tumor histologically characterized by detachment of endothelial cell-derived tumor cells. Since CAS expresses multiple angiogenic growth factors and has increased expressions of angiogenic receptor tyrosine kinase transcripts including VEGFR1/2/3, angiogenesis-promoting factors are potential drug targets in CAS.
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