4,5,6,7-Tetrachloro-2-(1H-imidazol-2-yl)isoindoline-1,3-dione

Sebastian Wölfel,Maximilian Wabnik,Michael Haese,Renate Schnerre,Conrad Kunick,Janine Joostberends,Jessica Friedrichs,Frederik Berndt,Bader Masri

doi:10.3390/m785

Abstract

4,5,6,7-Tetrachloro-2-(1H-imidazol-2-yl)isoindoline-1,3-dione was obtained by reaction of 2-aminoimidazole with 3,4,5,6-tetrachlorophthalic anhydride in refluxing acetic acid.

Highlights

4,5,6,7-Tetrachloro-2-(1H-imidazol-2-yl)isoindoline-1,3-dione was obtained by reaction of 2-aminoimidazole with 3,4,5,6-tetrachlorophthalic anhydride in refluxing acetic acid
In a recent paper members of the compound class were described as inhibitors of the protein kinase CK2 [5]
In the course of our studies on protein kinases and their ATP-competitive ligands [6,7,8,9] we were interested in structurally new Nsubstituted tetrachlorophthalimides as putative protein kinase inhibitors

Summary

Introduction

Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, D-38106 Braunschweig, Germany Abstract: 4,5,6,7-Tetrachloro-2-(1H-imidazol-2-yl)isoindoline-1,3-dione was obtained by reaction of 2-aminoimidazole with 3,4,5,6-tetrachlorophthalic anhydride in refluxing acetic acid. Members of this compound class have been reported as biological response modifiers through regulation of tumor necrosis factor α [1], as α-glucosidase inhibitors [2], as liver X receptor antagonists [3], and as antihyperlipidemic agents [4]. In a recent paper members of the compound class were described as inhibitors of the protein kinase CK2 [5].

Results

Conclusion