#4556 IMPACT OF KIDNEY DONATION ON PREGNANCY OUTCOMES: A RETROSPECTIVE ANALYSIS

Abstract

Abstract Background and Aims More than 50% of living kidney donors are females with a significant proportion being in the childbearing age group. Recent data suggests risk of gestational hypertension, proteinuria and pre-eclampsia among pregnancies after kidney donation with a lower likelihood of full-term delivery. Method This retrospective study was conducted among females who donated kidney between (1997 - 2017) at a tertiary renal transplant centre in Northern India to assess for consequences of pregnancy outcomes among donors in terms of maternal and foetal outcomes.. Data of participants were collected using pre-tested semi structured questionnaire. Results 925 female kidney donors (1332 pregnancies) in the pre donation group while 45 females (48 pregnancies) in the post donation period were included . Mean age of first pregnancy, weight (kg) gain, proportion of history of pre-natal check-up and history of unrelated donation was statically significant among the post -donation group . The proportion of pre-eclampsia, gestational hypertension, gestational diabetes, post-partum hemorrhage was insignificantly higher among post donation group with higher preterm birth with low birth weight babies . In Univariate analysis, Cesarean delivery, proteinuria and low birth weight <2500g were significantly associated with post donation pregnancy. While Cesarean delivery (Adjusted odds ratio: 8.2, 95% CI: 4.7-14.3, P = .024) and low birth weight < 2500g (Adjusted odds ratio: 6.3, 95% CI: 2.3-11.8, P = .003) were identified as an independent determinant among post donation pregnancies using multivariate analysis . Conclusion The study demonstrated not a large risk to maternal outcomes yet an increase risk to fetal outcomes in terms of prematurity and low birth weight among the post donation pregnancy group.