Abstract
Tumor-infiltrating immune cells (TIICs) play critical roles during the development and progression of cancers. However, only a few studies have investigated the niches of immune cells in melanoma using spatial transcriptomics, which may increase our mechanistic understanding of the immune phenotypic dynamics during tumor progression. Here, we aimed to elucidate the differential gene expression profiles of TIICs related to melanoma progression and to explore the intra-tumoral immune landscape. A formalin-fixed paraffin-embedded block was prepared with a single excision specimen from a patient with simultaneous multiple stages of melanoma in a single lesion, and profiled using spatial transcriptomics, with a focus on TIICs.
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