455-P: Waist–to–Body-Mass-Index Ratio Independently from Type 2 Diabetes Predicts MACE in Patients with Cardiovascular Disease

Abstract

Waist circumference reflect central fat accumulation and is an important additive information to BMI. The Waist Circumference-to-Body-Mass-Ratio (W/BMI-Ratio) has been suggested to provide additional information on cardiovascular event risk. Its power to predict cardiovascular events in patients with established cardiovascular disease is not known and is addressed in the present study. We prospectively recorded cardiovascular events in 1833 patients with angiographically verified coronary artery disease or sonographically proven peripheral artery disease. The mean follow-up time was 9.4±5.1 years. At baseline, there was no significant difference in the W/BMI-Ratio between patients with and those without T2DM (3.6±0.3 vs. 3.6±0.3; p=0.465). Prospectively, the W/BMI-Ratio significantly predicted the incidence of MACE (n=716) both univariately (standardized HR 1.46 [1.18-1.80], p<0.001) and after adjustment for age, gender, smoking, LDL cholesterol, HDL cholesterol, hypertension and T2DM (standardized adjusted HR=1.29 [1.02±1.63], p=0.032); HRs were 1.29 [1.02±1.85], p=0.013 in patients without diabetes and 1.08 [0.98-1.21], p=0.138 in those with diabetes, with a non-significant p for interaction W/BMI-Ratio x diabetes status. We conclude that the W/BMI-Ratio independently from diabetes status is a predictor for MACE in patients with established cardiovascular disease. Disclosure A.Mader: None. C.H.Saely: None. L.Sprenger: None. A.Vonbank: None. B.Larcher: None. M.Maechler: None. T.Plattner: None. A.Leiherer: None. A.Muendlein: None. H.Drexel: None.