451 Prognostic Impact Of Progression Of Aortic Valve Calcification On The Development Of Aortic Stenosis: Results From The Multi-ethnic Study Of Atherosclerosis (mesa)

Abstract

Introduction: Aortic stenosis (AS) is the most common primary valve disease in Europe and the United States. The prevalence of severe AS is estimated to be around 1 million by 2025, and survival without valve replacement is about 2-3 years. It is therefore imperative to develop strategies for the early identification and risk stratification of patients with AS. Although valvar calcification is a known intrinsic mechanism leading to AS, the impact of Aortic valve calcium (AVC) progression on the development of AS is unknown