Abstract
Breast cancer is one of the most common malignancies among women. MCF-7 are hormone-dependent while MDA-MB-231 are triple-negative. Estrogen receptors (ERs) play a critical role in breast cancer progression, modulating thereby the expression of long non-coding RNA (H19) and telomerase (hTERT), regulating thereafter glycolytic enzymes as PKM2 and LDHA. miR-let-7a a tumor suppressor could be antagonized by high expression of H19. All-trans retinoic acid (ATRA) has a major role in cell proliferation and differentiation after solid tumors treatment, like breast cancer.
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