Abstract
Ferroptosis is a recently described form of regulated cell death gaining significant interest for its involvement in a variety of disease states. It is broadly defined by iron-dependent, lethal accumulation of lipid peroxides and dysregulation of cellular redox homeostasis. However, both a physiologic role for ferroptosis and how it functions in skin homeostasis remains elusive. Recent evidence from our lab identified a critical link between ferroptosis, the epigenetic tumor suppressor MLL4, and epidermal differentiation (Egolf et al., Science Advances, 2021).
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