Abstract
In this presentation, we will review the conduct, results and impact of two types of pregnancy hypertension-oriented clinical trials. First we will describe the CHIPS trial that randomised 987 women with non-proteinuric pregnancy hypertension in 95 sites in 16 countries. In the series of CHIPS trial publications there has been a consistent message that tight blood pressure control (target dBP = 85 mmHg) offers maternal safety without perinatal harm, and that methyldopa is a reasonable first choice of antihypertensive. Second, we will describe the CLIP trials that recruited 69,445 women in 44 clusters (unit of randomisation) in Mozambique (12 clusters), Pakistan (20 clusters) and India (12 clusters). The results will be summarised and implications of both types of trials and their results for widespread implementation discussed.
Published Version
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