Abstract
Changes in the abundance and organization of lipid lamellae (LL) in the stratum corneum (SC) are proposed to underly barrier dysfunction in conditions such as psoriasis, atopic dermatitis and ichthyosis. However, there are few reports on LL organization in diseased SC. The current investigation tested the hypothesis that LL organization is altered in omega-O-acylceramide metabolism defects associated with congenital ichthyosis. Pnpla1 and Alox12b knockout mice were used as experimental models with defective omega-O-acylceramide synthesis and oxidation, respectively, and LL organization was quantitatively evaluated by electron microscopy.
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