Abstract
Purpose: Chronic rejection, characterized by myocardial fibrosis and cardiac allograft vasculopathy (CAV) is the leading cause of allograft loss in heart transplant recipients. During alloimmune response, expression of many growth factors, such as platelet-derived growth factor (PDGF), is induced. The PDGF family consisting ligands (AA, AB, BB, CC, DD) acts mainly on mesenchymal origin cells and is a potent mitogenic and chemotactic factor for fibroblasts and vascular smooth muscle cells. In this study we characterized the specific roles of PDGF ligands in chronic rejection.
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