441. LMW heparin and recurrent placenta-mediated pregnancy complications: An individual participant data meta-analysis

Abstract

Placenta-mediated pregnancy complications, including pre-eclampsia, placental abruption, birth of a small-for-gestational age infant and late pregnancy loss, are common and cause significant morbidity and mortality. The use of antepartum low-molecular-weight heparin (LMWH) prophylaxis to prevent recurrent placenta-mediated pregnancy complications became common practice despite limited and conflicting evidence supporting its use. Unfortunately, differences in the study design of individual randomized controlled trials have limited comparison across trials. In this talk we will review data from an individual patient data meta-analysis that challenges the role of LMWH in preventing recurrent placenta-mediated pregnancy complications.