Abstract
Publisher Summary This chapter discusses the synthesis of coenzyme A and its biosynthetic intermediates by microbial processes. CoA is prepared by extraction from microorganisms and by chemical synthesis. However, these methods are not practical because of their low yields or their complexity. Simple and rapid microbial methods for the preparation of CoA and its biosynthetic intermediates are described in the chapter. CoA is enzymically synthesized from pantothenic acid, cysteine, and adenosine triphosphate (ATP) by cells of Brevibacterium ammoniagenes. CoA is synthesized in high yield from pantothenic acid, cysteine, and ATP when these are incubated with dried cells of Brevibacterium amrnoniagenes as the enzyme. The synthesis of intermediates of CoA biosynthesis is also described in the chapter. CoA and all the intermediates of CoA biosynthesis, with the exception of 4'-phosphopantothenoylcysteine, are synthesized selectively with high yields by use of the individual reactions involved in the CoA biosynthetic pathway. Both the dried cell method and the fermentative method can be used.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
