44. RELATIONSHIP BETWEEN HYPERTENSION AND HYPONATREMIA IN CORONAVIRUS DISEASE PATIENTS: A CROSS-SECTIONAL STUDY

Abstract

Background : Hypertension has been presumed to be associated with the severity of coronavirus disease (COVID-19) related to angiotensin-converting enzyme 2 (ACE2). Besides, hyponatremia is the most common electrolyte disorder in COVID-19 patients and has been reported to be associated with increased mortality. Objective: This study aimed to evaluate the association between hypertension and hyponatremia in COVID-19 patients who were admitted to Wahidin Sudirohusodo General Hospital Mojokerto. Method: In this study, we cross-sectionally investigated COVID-19 patients who were admitted to Wahidin Sudirohusodo General Hospital Mojokerto between December 2020 and January 2021. According to medical records, we evaluated COVID-19 patients who have hypertension as comorbidities and hyponatremia from laboratory results. Result: There were 98 COVID-19 patients consisted of 50 men and 48 women included in this study. The mean number of patients’ age was 55.6 ± 12.4 years. The prevalence of hypertension among patients was 55.1%. The mean number of sodium level was 131.50 ± 11.29 mmol/L. There was a strong correlation between blood pressure and sodium balance disorders (p < 0.002). Hypertension was associated with a nearly 5.5-fold increased risk of hyponatremia in COVID-19 patients (OR 5.06; 95% CI: 1.66–15.4; p < 0.05). Conclusion: Hypertension comorbidity was associated with a higher risk of hyponatremia in COVID-19 patients.