439: Detection of large-scale deletions in mitochondrial DNA using DNA extracted from salivary samples

Abstract

s / Journal of Clinical Neuroscience 15 (2008) 337–369 355 Results: Two of 35 (6%) patients had peri-operative strokes. Sixteen of 32 (50%) with post-operative imaging had new ischemic lesions including 5 of 6 with combined cardiac valve and CABG surgery. There were a range of 1–17 lesions, each <1 cm diameter except in 3 patients with large confluent areas of ischemia. Twenty of 29 (69%) patients with post-operative testing had significant cognitive declines in at least one domain (range 1–4), including all those with new ischemic lesions (p = 0.005). Conclusion: Brain injury is common following cardiac valve surgery: 6% have new neurological deficit and just over two thirds have measurable cognitive decline. Half of the patients had new post-operative ischemic lesions on DWI and these appeared embolic in nature. To our knowledge, this is the first study to link cognitive decline and cerebral ischemia. Cardiac surgery may be a useful model of human stroke in late phase IIB trials of putative neuroprotective therapies. doi:10.1016/j.jocn.2007.07.049 439: Detection of large-scale deletions in mitochondrial DNA using DNA extracted from salivary samples Himesha Vandebona , Con Yiannikas , Carolyn M. Sue ; Department of Neurogenetics, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, Australia; Department of Neurology, Concord