Abstract
Adenosine A2a receptor (A2AR) blockade in combination with anti-programmed death-1 (PD-1) antibody (Ab) may alleviate immune-suppression, reduce tumor growth, and increase antitumor activity of anti-PD-1 Ab. Taminadenant (A2AR antagonist) +/- spartalizumab (anti-PD-1 Ab) has preliminary antitumor activity in a Ph Ib study in non-small cell lung carcinoma. We present results of taminadenant + spartalizumab in a Ph II study in MSS CRC (NCT03207867).
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Schedule a callMore From: Annals of oncology : official journal of the European Society for Medical Oncology
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