436: Combined Ex Vivo IL-4 and IL-10 Gene Therapy Reduces Chronic Rejection in Cardiac Allografts

G Cui,H Furukawa,J Xu,H Laks,L Sen

doi:10.1016/j.healun.2008.11.443

436: Combined Ex Vivo IL-4 and IL-10 Gene Therapy Reduces Chronic Rejection in Cardiac Allografts

G Cui, H Furukawa + Show 3 more

https://doi.org/10.1016/j.healun.2008.11.443

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Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Publication Date: Jan 24, 2009

Affiliation: University of California, Los Angeles

#Chronic Rejection In Cardiac Allografts #Rejection In Cardiac Allografts + Show 8 more

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Abstract

We have previously shown that locally overexpressed exogenous interleukin-4 (IL-4) and interleukin-10 (IL-10) in cardiac allografts synergistically inhibited alloimmune response and acute rejection in rabbit heart transplant model. The mean survival of cardiac allograft was prolonged from 7±1 days in Control Group (CG) to 134±10 days in IL-4 and IL-10 combined gene therapy Group (IL-4&10G).

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