435 Use of Vitamin K and Prothrombin Complex Concentrate as Warfarin Reversal Prior to Heart Transplant

Abstract

creatinine (Cr), hemoglobin, BNP and EF values were recorded as well as peripheral tissue oxygenation (SpO2). Results: The mean resting SctO2 value was 65.1 7.6% (range, 42.9 76.3%). The difference between cerebral and peripheral tissue oxygenation (SpO2-SctO2) was 32.1 8.0% (range, 19.2 51.4%). There was a significant correlation between both SctO2 (positive) and SpO2-SctO2 (negative) on 5 variables: systolic, diastolic, mean arterial blood pressure, EF and serum BNP (p 0.01). Importantly, pts with BNP 100pg/ml had significantly higher SctO2 and smaller SpO2-SctO2 compared to those with BNP 100pg/ml (p 0.0001). Similar results were evident for pts with EF 50 or 50% (p 0.01), as well as Cr 1.0 or 1.0 mg/dl (p 0.05). Additionally, wider SpO2-SctO2 differences were noted in smokers and pts with prior CVA (p 0.05). Conclusions: SctO2 is a safe and easily obtained measurement and correlates with well-established biomarkers in HF pts. A range of SctO2 exists in symptomatic HF pts despite normal SpO2. SctO2 monitoring has the potential to investigate target organ perfusion and, hence, may allow non-invasive and economical disease status monitoring as well as offer insights into disease progression, co-morbidity and guide management. SctO2 is an important biomarker.