Abstract
Respiratory syncytial virus (RSV) is a massive medical burden in infants and children worldwide, and an effective and safe RSV vaccine remains an unmet need. Here we report a novel vaccination strategy to deliver a pDNA vaccine encoding RSV-F using a surface electroporation device (SEP) to target epidermal cells in clinically relevant experimental models. We demonstrate the ability of this strategy to target epidermal Langerhans cells, and elicit robust cellular and humoral immune responses. In the cotton rat challenge model we demonstrate complete resistance to pulmonary infection after delivering a single low dose of vaccine. In contrast to the formalin-inactivated RSV (FI-RSV) vaccine there was no enhanced lung inflammation upon virus challenge after pDNA vaccination. In summary the data presented outlines the pre-clinical development of a highly efficacious, tolerable and safe non-replicating vaccine strategy against RSV.
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