Abstract
In growth hormone neurosecretory dysfunction (GHND), poor growth is due to low 24-h integrated concentration of GH (IC-GH) even though the response to paired pharmacologic stimulation (PS) of GH is normal. We compared the GH response to 1 μg/kg hpGRH-40 of 8 GHND children, 4 children with subnormal GH responses to paired PS tests and subnormal IC-GH (GHD), and 3 short children with normal PS and normal IC-GH (NORMAL SHORT). The peak GH response to hpGRH-40, PS stimulation and IC-GH of the 3 groups is presented as mean±lSD in ng/ml: The response to hpGRH-40 of GHND children was significantly higher than the other groups. Conclusion: 1/GHND children have an increased reserve of releasable GH. 2/GHND lack the neurologic GRH releasing mechanism to maintain adequate spontaneous GH release. 3/The increased response of GHND to hpGRH-40 may be of diagnostic value.
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