Abstract
Introduction and aims of the study: It’s been hypothesized that it may be possible to use cffDNA, cffRNA and microRNA to identify high-risk pregnancies and placental-mediated pregnancy complications such as preterm birth (sPB), preeclampsia (PE), fetal growth restriction (FGR) and gestational diabetes (GDM). This review presents the current evidence for this hypothesis. Methods: 643 records were identified through database searching, of which 90 were included. Results: Most, but not all, studies were able to demonstrate an association between the amount of cffDNA, the fetal fraction and PE.
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