432P Survival pattern of non-metastatic non-small cell lung cancer (NSCLC) in the United States

Abstract

Background Tumor size and lymph node infiltration are known to be prognostic factors in different stages of non-small-cell lung cancer (NSCLC), the aim of this study is to show the effect of different treatment modality with different stage on survival rate. Methods: The data were obtained from all 18 SEER database registries which were used to identify patients diagnosed with non-metastatic non-small cell lung cancer between 1988-2003. Relative five-year survival was calculated & compared between patient according to American Joint Committee on Cancer 6th edition classification with surgical and/or radiation intervention for treatment. Results 6133 patients in the SEER databases who met the selection criteria. 57.7% was male, 82.1% was white. 56.8% of the patient has the primary lesion in the upper lobe of the lung. According to American Joint Committee on Cancer 6th edition 45.1% of the patient had T4 stage and 47.9% had N2 stage. All T stages showed significant difference of 5 years relative survival (P > 0.05) with surgical intervention only except T3 stage which showed significant difference of 5 years relative survival (P > 0.05) with surgical intervention and radiation therapy. N0 and N1 stage showed significant difference of 5 years relative survival (P > 0.05) with surgical intervention only but N2 showed significant difference of 5 years relative survival (P > 0.05) with surgical intervention and radiation therapy. Conclusions Surgical intervention alone has significant higher 5 years relative survival rate with most of stages of NSCLC. However radiation therapy will be needed with surgical intervention in T3 and N2 stages. Legal entity responsible for the study Ahmed Meshref Funding Ahmed Meshref Disclosure All authors have declared no conflicts of interest.