Abstract
Optimising treatment strategies for patients with mCRC responding to first line chemotherapy has important connotations for quality of life, toxicity and prudent health care. Current standards in national guidelines support a strategy of ongoing chemotherapy until disease progression or excess toxicity. Trial level meta-analysis has indicated that complete treatment breaks may not detrimentally affect survival, however, breaks from treatment are not universally offered. FOCUS4-N explores the impact of oral capecitabine (C) maintenance in patients (pts) who are responding to first line therapy.
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