Abstract
Cutaneous squamous cell carcinoma (cSCC) is one of the most common and fastest increasing forms of cancer worldwide with metastatic potential. Long non-coding RNAs (lncRNAs) are a group of RNA molecules with essential regulatory functions for both physiological and pathological processes. In this study, we identified plasmacytoma variant translocation 1 (PVT1) as a lncRNA upregulated in cSCC compared to healthy skin and to precancerous lesions (actinic keratosis). In situ hybridization analysis of PVT1-expression on a large cohort of cSCCs and precancerous lesions revealed that increased PVT1-expression is associated with the invasive phenotype.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
