Abstract
Cutaneous squamous cell carcinoma (cSCC) is one of the most common and fastest increasing forms of cancer worldwide with metastatic potential. Long non-coding RNAs (lncRNAs) are a group of RNA molecules with essential regulatory functions for both physiological and pathological processes. In this study, we identified plasmacytoma variant translocation 1 (PVT1) as a lncRNA upregulated in cSCC compared to healthy skin and to precancerous lesions (actinic keratosis). In situ hybridization analysis of PVT1-expression on a large cohort of cSCCs and precancerous lesions revealed that increased PVT1-expression is associated with the invasive phenotype.
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