431: Protein expression and enzymatic activity of superoxide dismutase in the fetal brain in a mouse model of fetal alcohol syndrome

Abstract

fetuses with enlarged bladder, bilateral hydronephrosis and normal amniotic fluid volume, diagnosed and enrolled between 20-24 weeks gestation. Exclusion criteria included cystic renal parenchyma, other anomalies, multiple gestation, membrane separation, no karyotype, and cervical length of 1.5cm. Ultrasound evaluation of AFV, renal and bladder dimensions were obtained at 24, 28 and 32 weeks. Delivery and neonatal discharge data were collected. Prospective outcome data at 12 and 24 months is currently being collected. RESULTS: Twenty-seven patients have enrolled. Mean GA at enrollment was 22.7 weeks. Mean AFV at enrollment was 15.9cm (9.5-20.1). One patient underwent TOP. One patient delivered at 27 weeks with a NND at DOL 24 secondary to complications of prematurity. Eight patients remain undelivered. Mean AFV at 32 weeks was 11.6cm (026.7). Delivery data was available for 18 patients. Mean GA at delivery was 39.1 weeks (26.6-40.4). Mean BW was 2910g (1000-3735). CD was performed primarily for fetal malpresentation or history of prior CD. 43% (6/14) demonstrated a normal neonatal serum Cr, while 57% (8/14) demonstrated abnormal neonatal Cr at the time of discharge. Postnatal diagnosis was available for 16 neonates: PUV 50% (9/18) and TRIAD 38.8% (7/18). 55.5% (10/18) neonates required initial respiratory support, but all were discharged on room air. Spontaneous voiding was documented in 55.5% (10/18) neonates at discharge. CONCLUSION: Fetuses with prenatally diagnosed obstructive uropathy and normal AFV are not at increased risk for preterm delivery as reported in LUTO with oligohydramnios. Respiratory and renal functions appear to be preserved in the majority of affected neonates at time of discharge.