43. The 3d-pd features of fetal middle cerebral with severe preeclampsia

Abstract

Background The prevalence of preeclampsia was approximately 4.0% and 2.88% of all pregnancies worldwide and in mainland China. It is mainly characterized by the poor remodeling of the uterine spiral artery and the superficial implantation of placenta, which will contribute to maternal and neonatal complications. Objective The aim was to explore the changes of fetal middle cerebral artery flow indices and its relationship with severe preeclampsia. Methods From August 2016 to February 2017, 56 women with severe preeclampsia who hospitalized in the obstetric ward of the first affiliated hospital, Xi’an Jiaotong University were included as research group. 64 normal pregnant women without any complications during the same period were randomly selected as the control group. The matching principles are ±3 years age of maternal age and ±3 of gestational weeks. Color Doppler ultrasound were performed by GE Voluson E8. PI and RI of fetal middle cerebral artery and of umbilical artery were tested. VI, FI and VFI was calculated by VOCAL. Results The UA-PI was 0.94 (0.57–1.55) and UA-RI was 0.61 (0.44–0.83) in research group. CPR (PIMCA/PIUA) was significantly lower in research group [1.63 (0.73–3.02‰ vs. 1.85 (0.67–3.02‰, p = 0.019]. There were no significant differences in MCA-PI, MCA-RI and VI, FI and VFI of MCA between the two groups. There was a negative correlation between CPR and stillbirth or neonatal death in the research group (r was −0.294 and −0.306, p was 0.047 and 0.039 respectively). In the adverse perinatal outcome of research group, CPR was 1.66 (0.73–3.02‰). It was significantly higher compared with that of good perinatal outcome. When the cut-off values of CPR was taken as 1.05, 1.10, 1.15, respectively, the sensitivity was 7.7%, 12.8%, 17.9% and specificity was 100%, 100%, 87.5%, respectively, for predicting adverse perinatal outcome. Conclusion CPR could be used as predictive index for adverse outcome with severe preeclampsia.