Abstract
Background: The chemotherapeutics used today mostly suffer from selectively targeting tumor cells. Unlike normal cells, cancer cells frequently exhibit extra centrosomes, which tend to form multipolar spindles (MPS), triggering cell death. Nevertheless, cancer cells divide successfully by clustering their extra centrosomes into two poles. Nek2 kinase is a key molecule regulating mitotic processes, including centrosome cycle, kinetochore attachment, microtubule organization, and spindle assembly checkpoint.
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