Abstract
Background: Interleukin-15 (IL-15) is a critical cytokine involved in the activation, proliferation and survival of natural killer (NK) and CD8+ T cells. The high-affinity IL-15 receptor (IL-15Rα) expressed on monocytes and dendritric cells supplies IL-15 in trans to NK and T cells. Tumor cells engineered to express IL-15Rα may enhance the immune response to tumor. We studied the antitumor activity of adenoviral-mediated transfer of the murine IL-15Rα gene in a mouse breast cancer model.
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