Abstract
MNK-155 contains 7.5 mg hydrocodone bitartrate and 325 mg acetaminophen in an immediate-release (IR)/extended-release (ER) tablet formulation utilizing AcuForm™ gastroretentive drug delivery technology. MNK-155 (HB/APAP ER) is under development for the management of moderate to moderately severe acute pain with 12-hour dosing. This study evaluated the extent to which MNK-155 intact, MNK-155 crushed, and IR HB/APAP (Norco®) produce certain subjective effects that have been associated with drug abuse in recreational opioid users, such as drug liking, high, and good drug effects.
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