425-P: Association between Neuropathy and Periodontitis among Type 2 Diabetes Patients

Abstract

Introduction: Among the oral mucosal infections such as Periodontal Diseases, (PD) there is a strong correlation between systemic metabolic conditions such as type 2 diabetes (T2D). Moreover, there is growing evidence that Diabetic Neuropathy (DN) is associated with increased risk for foot ulceration. However, little is known how DN would correlate with the PD status. Aim: The aim of this study was to determine how the diabetes status as exemplified by the state of HbA1c levels and DN would correlate with the status of PD. Materials and Methods: T2D patients with and without PD, who visited the dental department of a diabetes hospital were included in the study. Patients without PD (n = 494) and with PD (n = 493) were recruited based on probing depth of >4mm/clinical attachment loss of >3mm (mild to moderate PD) according to the diagnostic criteria of the American Academy of Periodontology. Body mass index, fasting blood glucose, postprandial blood glucose and HbA1c were measured. Neuropathy was assessed by biothesiometry. Results: There was a significant difference in the age, duration of diabetes, glycemic levels and presence of neuropathy between the 2 groups (Table). In the regression analysis, neuropathy was highly significant (p Conclusion: The study shows a strong association between PD and DN among T2D patients. Disclosure R. Vinitha: None. A. Ramachandran: None. M. Muthukuru: None. K. Satheesh: None. R. Yogalakshmi: None. A. Rajeswari: None. L. Sundar: None. A. Nanditha: None. A. Raghavan: None. C. Snehalatha: None. Funding India Diabetes Research Foundation