425: Multi-vessel Doppler parameters for the prediction of adverse neonatal outcome in the preterm growth-restricted fetus: does gestational age matter?

Abstract

with a birthweight less than the 10th percentile without malformations were included. Group A (study group); GRF delivered at term without other clinical signs of PI. Group B, (1st control group); GRF accompanied with clinical signs of PI and delivered at term. Group C, (2nd control group), GRF accompanied with early severe preeclampsia, placental abruption or abnormal Doppler and delivered before 34 weeks. Group D, (3rd control group); term placentas from healthy women who delivered fetuses appropriate for age. Placental lesions examined included maternal and fetal vascular obstructive lesions, villitis and perivillous fibrinoid deposition. Primary outcome was the incidences of placental lesions among the study group compared to the controls. RESULTS: The most frequent placental lesions found among all groups were maternal obstructive lesions (Table). For women in group A, the odds of having any maternal obstruction lesion was 3.3 times higher than women in group D (p 0.0006). There were no differences between groups A and B (p 0.98). The incidence of any obstructive maternal lesion was significantly higher among group C compared to group A (p 0.0004) and B (p 0.0003). The incidence of any placental lesion was significantly higher among all the groups with GRF (A, B and C) compared to group D. The incidence of any lesion among group A (69.4%) was 7.9 times higher than women in group D (22.3%) (p 0.0001) and comparable to group B (61.7%), (p 0.3). CONCLUSION: The incidence of placental lesions among GRF delivered at term was comparable regardless of whether clinical signs of PI exist or not. Antepartum management of GRF at term probably needs to be similar regardless of other signs of PI.