Abstract
We have measured Zinc (Zn) levels in different tissues of castrated rats (CR) fed purified diet containing 100 pp Zn for 6 wks with and without injection of testosterone (T) enanthate (20 mg IM) 2 wks prior to sacrifice. CR had very low serum T (0.6 ± 0.1 ng/ml) as compared with the controls (8.2 ± 0.7 ng/ml) and T administration restored serum T to normal levels (9.1 ± 1.1 ng/ml).After castration, serum and tissue Zn levels were significantly decreased with concomitant increase in urinary Zn (see Table). Administration of T to CR increased the serum and tissue Zn levels almost to the normal level. Since food intake was similar in all groups, T in CR may have increased Zn retention. These results strongly suggest a positive relationship between Zn and T metabolism.
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