Abstract
Cell-material adhesion is generally considered to be mediated by extracellular matrix proteins (ECM) such as fibronectin. ECM increases cell adhesion, cell spreading, and cytoskeleton development, when they are coated onto material surface. In this study, we measured the cell adhesive shear force of murine fibroblasts to glass coated by ECM. We also measured focal adhesion area by interference reflection microscopy (IRM) and cytoskeleton deveopment by immunofluorescent staining to examine the effect of focal adhesion and cytoskeleton development on cell adhesive shear force. As a result, it becomes clear that the cell adhesive shear force depends on the focal adhesion area and the cytoskeleton development.
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