#4240 SUCCESSFUL PROPHYLAXIS WITH STROVAC VACCINE AGAINST URINARY TRACT INFECTION AFTER KIDNEY TRANSPLANTATION

Abstract

Abstract Background and Aims Urinary tract infections (UTI) are the most common of infections after renal transplantation with an estimated incidence between 10 and 98%. Recurrent urinary tract infections (rUTIs) increase mortality and reduce graft survival after renal transplantation. The present case describes an immunization strategy against bacterial strains after kidney transplantation. Method We administered urinary tract vaccine for prophylaxis for rUTIs after kidney transplantation. A kidney transplant recipient with 3 or more UTI episodes/year underwent immunization with 3 subcutaneous injections (once a week) of inactivated bacteria-StroVac (follow-up 12 months before to 12 months after immunization). StroVac contains 10 strains of inactivated bacteria (6 types of Escherichia coli, Proteus mirabilis, Morganella morganii, Enterococcus feacalis, Klebsiella pneumoniae). A year later the StroVac Booster was administered once. Urine culture analysis was given every 3 months for a year. Clinical and laboratory comparisons were made. The results were evaluated statistically. Results Before initiation of prophylaxis, patient had a UTI incidence of 5. The patient had symptoms such as fever, dysuria, or urgency and were positive in urine dipstick examination for pyuria or nitrituria. Vaccination with StroVac significantly reduced the incidence of UTI yielding a mean annual incidence of 1 (p<0.05). Conclusion StroVac is an effective and lasting non-antibiotic prophylaxis for rUTI, easy to administer with low rates of adverse events and should be offered to patients with rUTI after kidney transplantation.