423-P: The A Body Shape Index and Type 2 Diabetes Are Mutually Independent Predictors of Cardiovascular Events and Mortality in Patients with Established Cardiovascular Disease

Abstract

The A Body Shape index (ABSI) is a validated measure of visceral adiposity that is calculated based on waist circumference, height and BMI. Its power to predict cardiovascular events and mortality in patients with established cardiovascular disease (CVD) is unclear and is addressed in the present study. We prospectively recorded cardiovascular events in a large cohort of 1546 patients with established CVD (1299 patients with angiographically proven stable coronary artery disease and 247 patients with sonographically verified PAD) over a mean follow-up time of 9.7±4.6 years. At baseline, the ABSI was higher in patients with type 2 diabetes (T2DM; n=502) than in those who did not have diabetes (8.4±0.6 vs. 8.3±0.5; p<0.001). Prospectively, the ABSI significantly predicted the incidence of cardiovascular events (n=749) and death (n=619) after adjustment for age, gender, smoking, hypertension, LDL cholesterol, HDL cholesterol, and T2DM (standardized adjusted HRs 1.11 [1.03-1.19]; p=0.006 and 1.18 [1.09-1.27]; p<0.001, respectively). T2DM in turn also significantly predicted cardiovascular events and death in this fully adjusted model independently from the ABSI, with adjusted HRs of 1.37 [1.17-1.0]; p<0.001 and 1.40 [1.18-1.6]; p<0.001, respectively. We conclude that the ABSI and T2DM are mutually independent of cardiovascular events and mortality in patients with PAD. Disclosure A. Vonbank: None. B. Larcher: None. A. Mader: None. M. Maechler: None. L. Sprenger: None. A. Leiherer: None. D. Purin: None. A. Muendlein: None. H. Drexel: None. C.H. Saely: None.