Abstract
Lung transplant recipients have a high prevalence of gastroesophageal reflux and aspiration of gastric contents. Patients with gastric aspiration have a high risk of developing Bronchiolitis Obliterans Syndrome. LTx patients are frequently treated with PPI to reduce gastric acid secretion. It is unclear whether aspiration of gastric juice from patients “on” PPI can provoke a similar bronchial inflammatory reaction than that observed in patients “off” medication. The aim of this study was to evaluate the effect of gastric juice from patients with and without acid suppressive therapy (PPI) on production of IL-8 by human primary bronchial epithelial cells in vitro.
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