Abstract

Anlotinib is an oral multi-target tyrosine kinase inhibitor, mainly targets VEGFR1-3, FGFR 1-4, PDGFR α/β and c-kit. Previous trial has demonstrated that anlotinib monotherapy was effective and safe in advanced colorectal cancer following the failure of standard treatment. ALTER-C002 trial was designed to evaluate the efficacy and safety of anlotinib plus CAPEOX as first-line therapy in patients with RAS/BRAF wild-type unresectable metastatic colorectal cancer (mCRC). Preliminary results demonstrated significant antitumor activity and manageable toxicity.

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