Abstract
Neuroendocrine growth factors help regulate thymic function and serve as potential agents to accelerate thymic T-cell production following hematopoietic stem cell transplantation (HSCT). We present evidence supporting insulin-like growth factor I (IGF-1) as a thymic regulator. Continuous infusion of IGF-1 (100 ug/day) into normal mice resulted in significant increases in all thymocyte populations, including earliest thymocyte precursors (ETP), with subsequent increases in recent thymic emigrants (RTE).
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